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Mahmood Belov
Mahmood Belov

Inheritance: How Our Genes Change Our Lives--an...



Introduction-Everything Is About to Change ixChapter 1 How Geneticists Think 1Chapter 2 When Genes Misbehave: What Apple, Costco, and a Danish Sperm Donor Teach Us about Genetic Expresssion 24Chapter 3 Changing Our Genes: How Trauma, Bullying, and Royal Jelly Alter Our Genetic Destiny 45Chapter 4 Use It or Lose It: How Our Lives and Genes Conspire to Make and Break Our Bones 59Chapter 5 Feed Your Genes: What Our Ancestors, Vegans, and Our Microbiomes Teach Us about Nutrition 82Chapter 6 Genetic Dosing How Deadly Painkillers, the Prevention Paradox, and Ötzi the Iceman Are Changing the Face of Medicine 108Chapter 7 Picking Sides: How Genes Help Us Decide Between Left and Right 123Chapter 8 We're All X-Men: What Sherpas, Sword Swallowers, and Genetically Doped Athletes Teach Us about Ourselves 139Chapter 9 Hacking Your Genome: Why Big Tobacco, Insurance Companies, Your Doctor, and Even Your Lover All Want to Decode Your DNA 155Chapter 10 Mail-Order Child: The Unintended Consequences of Submarines, Sonar, and Duplicated Genes 176Chapter 11 Putting It All Together: What Rare Diseases Teach Us about Our Genetic Inheritance 199Epilogue-One Last Thing 223Notes 227Index 243Acknowledgments 253About The Author 255Show Moreif(typeof performance.mark !== 'undefined' && typeof performance.measure !== 'undefined')performance.mark("Product_Tabs_loading_end");performance.measure("productTabsDur","Product_Tabs_loading_start","Product_Tabs_loading_end");Editorial ReviewsContrary to conventional wisdom, we are not held in bondage from birth by the double helix. As this book by geneticist Sharon Moulem (Survival of the Sickest) shows, our genes do determine some things, but its encodings are not immutable. He notes, for example, that a change in diet can actually alter genes and slow the aging process; while, on the other hand, a trauma can be passed genetically through generations. With its message of change, Inheritance both illuminates and empowers.




Inheritance: How Our Genes Change Our Lives--an...



"Dr. Moalem tells fascinating stories so you will easily understand the complexities of modern genetic science." —Temple Grandin, PhD, New York Times bestselling author of The Autistic Brain and Thinking in Pictures"In INHERITANCE, Sharon Moalem peels away at the complex discussion of nature and nurture by looking at how unique cases inform the fundamental system of genes, environments, and experiences-teaching us how our dynamic identities come into being."—Dan Ariely, PhD, James B. Duke Professor of Psychology and Behavioral Economics, Duke University and New York Times bestselling author of Predictably Irrational"This book is a thought provoking and most enlightening journey into the very essence of who we are. Dr. Moalem's writing style is clear and uses great examples to help us appreciate our genetic selves. In INHERITANCE we have a new understanding that we are not at all destined to any particular future or outcome encoded within our DNA. Indeed, the whole notion that life's events, trivial and non-trivial, shape who we are has profound consequences for how we live and, in fields like biotechnology, how this learning can help us better to diagnose, treat and cure- and to extend and enhance human life." —John F. Crowley, Chairman and CEO of Amicus Therapeutics, and author of Chasing Miracles: The Crowley Family Journey of Strength, Hope and Joy"Dr. Moalem is an eloquent guide through the astonishing new world of genetic discovery - with all its implications for both personal health and public policy. If you've wondered about the impact of genetics on your life- read this book!" —Kinney Zalesne, New York Times bestselling author of Microtrends: The Small Forces Behind Tomorrow's Big Changes"We have long thought that the genetic code we were born with was the genetic code we were stuck with. No longer. Dr. Moalem explains how the genetics that determine whether we get sick or stay healthy can change during the course of our lifetime, and we how can exert some control over these changes. In this exceedingly engaging and highly informative book, Dr. Moalem uses engrossing stories to make complicated genetics easily comprehensible to people without backgrounds in the biological sciences. Reading this book could literally affect generations to come." —J. Russell Teagarden, PhD. Senior Vice President, Medical and Scientific Affairs, National Organization For Rare Disorders (NORD)"Many people will enjoy reading this easy to read book on a very complex, real and highly personal subject. It will remove mysteries and create others. It will give the lay reader a sense of the rapidly growing understanding of this field. I highly recommend it to everyone." —Henri A. Termeer, Former CEO and President of Genzyme Corp."Inheritance is a wide-ranging and breezily written survey of an immensely important field-the science of how we may "tweak" our fixed genetic heritage to produce health and well-being. The narrative moves quickly... It is especially thrilling for a geneticist, of all people, to emphasize "it's not only what our genes give us that's important, but also what we give to our genes." —Scientific American


Yes, cancer is a genetic disease. It is caused by changes in genes that control the way cells grow and multiply. Cells are the building blocks of your body. Each cell has a copy of your genes, which act like an instruction manual.


Genetic changes can lead to cancer if they alter the way your cells grow and spread. Most cancer-causing DNA changes occur in genes, which are sections of DNA that carry the instructions to make proteins or specialized RNA such as microRNA.


This is the process of epigenetics, where the readability, or expression, of genes is modified without changing the DNA code itself. Tiny chemical tags are added to or removed from our DNA in response to changes in the environment in which we are living. These tags turn genes on or off, offering a way of adapting to changing conditions without inflicting a more permanent shift in our genomes.


But more remarkable is that, two generations later, the offspring of those mice were still showing the same type of behavior. The scientists found that the trauma caused a change in two genes called Mecp2 and Crfr2, both of which are also found in humans.


Our genes can tell us a lot about who we are, but there are limits. Not only can the same gene act differently in different people; external influences, even the smallest daily actions, can also have a physical impact on your genome. By learning more about this intricate relationship, and making the appropriate lifestyle changes, you can make sure your genes stay undamaged.


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_OC_InitNavbar("child_node":["title":"My library","url":" =114584440181414684107\u0026source=gbs_lp_bookshelf_list","id":"my_library","collapsed":true,"title":"My History","url":"","id":"my_history","collapsed":true,"title":"Books on Google Play","url":" ","id":"ebookstore","collapsed":true],"highlighted_node_id":"");Inheritance: How Our Genes Change Our Lives, and Our Lives Change Our GenesSharon MoalemHachette UK, Apr 10, 2014 - Science - 352 pages 3 ReviewsReviews aren't verified, but Google checks for and removes fake content when it's identifiedA groundbreaking book that will transform how we understand ourselves and our families by revealing that everything we thought we knew about genetics is wrong. Your experiences, no matter how seemingly inconsequential - from bullies to crushes to what you eat for dinner - have all left an indelible mark within you. And more importantly, within your genes.Inheritance is a guidebook for change. No longer do we have to settle for what we've been given. We can write our own story.We're taught that we don't have much of a choice in the matter of what we get or what we give, because our genetic legacy was fixed when our parents conceived us. But that's all wrong. Our genes are constantly on the move, some are turning on while others are turning off, all in response to what you're doing, what you're seeing, and what you're feeling. And all of those things can be changed, which means we can change. Genetically.


Still, scientists have learned that certain changes in the DNA inside normal bone marrow cells can cause them to grow out of control and become leukemia cells. DNA is the chemical in our cells that makes up our genes, which control how our cells function. We usually look like our parents because they are the source of our DNA. But our genes affect more than how we look.


A common type of DNA change that can lead to leukemia is known as a chromosome translocation. Human DNA is packed into 23 pairs of chromosomes. In a translocation, DNA from one chromosome breaks off and becomes attached to a different chromosome. The point on the chromosome where the break occurs can affect oncogenes or tumor suppressor genes. For example, a translocation seen in nearly all cases of childhood chronic myeloid leukemia (CML) and in some cases of childhood acute lymphocytic leukemia (ALL) is a swap of DNA between chromosomes 9 and 22, which leads to what is known as the Philadelphia chromosome. This creates an oncogene known as BCR-ABL, which helps the leukemia cells grow. Many other changes in chromosomes or in specific genes have been found in childhood leukemias as well.


Certain genes normally control how our bodies break down and get rid of harmful chemicals. Some people have different versions of these genes that make them less effective. Children who inherit one of these gene changes may not be as able to break down harmful chemicals if they are exposed to them. The combination of genetics and exposure might increase their risk for leukemia. 041b061a72


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